Cluster IV: Molecular Biology of P - The central Role of P in Signaling and Metabolism from Cells to Ecosystems

The overarching goal is to unravel the central role of P as a metabolic, signaling and regulatory molecule from molecular to ecosystem levels. In fact, P acquisition, mobilisation and assimilation involve various molecular mechanisms in microorganisms, plants and animals. Moreover, P plays a key role in signalling at the level of ecosystems, organisms and cells. Projects in this Cluster aim to analyse the molecular mechanisms related to the uptake of P from the environment into the organism, the distribution, storage and mobilisation of P within the organisms and its essential roles in the cellular metabolism as well as in the crosstalk of microorganisms, cells and tissues.


Anschubprojekte im Rahmen der Förderung des Leibniz-WissenschaftsCampus Phosphorforschung Rostock (WGL, ab 07/2019)

Baclofen: Entwicklung effizienter Produktionsverfahren für die Darstellung von Baclofen und hiermit verwandter pharmazeutischer Produkte (BMWi, AIF, 01/2020-09/2023)

Graduiertenschule II: Leibniz-WissenschaftsCampus Phosphorforschung Rostock (WGL, 07/2019-06/2023)

MitoBOX: The mitochondrial basis of hypoxia tolerance in marine mollusks (DFG, 02/2019-01/2022)



Iqbal, M.A., Ali, A., Hadlich, F., Oster, M., Reyer, H., Trakooljul, N., Sommerfeld, V., Rodehutscord, M., Wimmers, K., Ponsuksili, S. (2021): Dietary phosphorus and calcium in feed affects miRNA profiles and their mRNA targets in jejunum of two strains of laying hens. Scientific Reports 11: 1-19, DOI: 10.1038/s41598-021-92932-3

Oster, M., Reyer, H., Gerlinger, C., Trakooljul, N., Siengdee, P., Keiler, J., Ponsuksili, S., Wolf, P., Wimmers, K. (2021): mRNA Profiles of Porcine Parathyroid Glands Following Variable Phosphorus Supplies throughout Fetal and Postnatal Life. Biomedicines 9 [454]: 1-14, DOI: 10.3390/biomedicines9050454

Oster, M., Reyer, H., Keiler, J., Ball, E., Mulvenna, C., Ponsuksili, S., Wimmers, K. (2021): Comfrey (Symphytum spp.) as a feed supplement in pig nutrition contributes to regional resource cycles. Science of the Total Environment 796: 1-11, DOI: 10.1016/j.scitotenv.2021.148988

Ponsuksili, S., Hadlich, F., Reyer, H., Oster, M., Trakooljul, N., Iqbal, M.A., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2021): Genetic background and production periods shape the microRNA profiles of the gut in laying hens. Genomics 113 [4]: 1790-1801, DOI: 10.1016/j.ygeno.2021.04.018

Reyer, H., Oster, M., Ponsuksili, S., Trakooljul, N., Omotoso, A.O., Iqbal, M.A., Muráni, E., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2021): Transcriptional responses in jejunum of two layer chicken strains following variations in dietary calcium and phosphorus levels. BMC Genomics 22: 1-12, DOI: 10.1186/s12864-021-07814-9

Reyer, H., Sjöberg, P.J.R., Oster, M., Wubuli, A., Murani, E., Ponsuksili, S. Wolf, P. Wimmers, K. (2021): Mineral Phosphorus Supply in Piglets Impacts the Microbial Composition and Phytate Utilization in the Large Intestine. Microorganisms 9 [1197]: 1-10, DOI: 10.3390/microorganisms9061197


Falfushynska, H.I., Sokolov, E., Piontkivska, H., Sokolova, I. (2020): The Role of Reversible Protein Phosphorylation in Regulation of the Mitochondrial Electron Transport System During Hypoxia and Reoxygenation Stress in Marine Bivalves. Frontiers in Marine Science 7: 467, DOI: 10.3389/fmars.2020.00467

Gussone, N., Böttcher, M.E., Conrad, A.C., Fiebig, J., Pelz, M., Grathoff, G., Schmidt, B.C. (2020): Calcium isotope fractionation upon experimental apatite formation. Chemical Geology 551: 119737, DOI: 10.1016/j.chemgeo.2020.119737

Oster, M., Reyer, H., Trakooljul, N., Weber, F. M., Xi, L., Muráni, E., Ponsuksili, S., Rodehutscord, M., Bennewitz, J., Wimmers, K. (2020): Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization. International Journal of Molecular Sciences 21, 2762:, DOI: 10.3390/ijms21082762

Ponsuksili, S., Reyer, H., Hadlich, F., Weber, F., Trakooljul, N., Oster, M., Siengdee, P., Muráni, E., Rodehutscord, M., Camarinha-Silva, A., Bennewitz, J., Wimmers, K. (2020): Identification of the Key Molecular Drivers of Phosphorus Utilization Based on Host miRNA-mRNA and Gut Microbiome Interactions. International Journal of Molecular Sciences 21, 2818:, DOI: 10.3390/ijms21082818

Siengdee, P., Oster, M., Reyer, H., Viergutz, T., Wimmers, K., Ponsuksili, S. (2020): Morphological and Molecular Features of Porcine Mesenchymal Stem Cells Derived From Different Types of Synovial Membrane, and Genetic Background of Cell Donors. Frontiers in Cell and Developmental Biology 8: 601212, DOI: 10.3389/fcell.2020.601212

Sommerfeld, V., Huber, K., Bennewitz, J., Camarinha-Silva, A., Hasselmann, M., Ponsuksili, S., Seifert, J., Stefanski, V., Wimmers, K., Rodehutscord, M. (2020): Phytate degradation, myo-inositol release, and utilization of phosphorus and calcium by two strains of laying hens in five production periods. Poultry Science 99: 6797-6808, DOI: 10.1016/j.psj.2020.08.064

Sommerfeld, V., Omotoso, A.O., Oster, M., Reyer, H., Camarinha-Silva, A., Hasselmann, M., Huber, K., Ponsuksili, S., Seifert, J., Stefanski, V., Wimmers, K., Rodehutscord, M. (2020): Phytate degradation, transcellular mineral transporters, and mineral utilization by two strains of laying hens as affected by dietary phosphorus and calcium. Animals 10: 1-21, DOI: 10.3390/ani10101736

Zwicker, J., Smrzka, D., Steindl, F., Böttcher, M.E., Libowitzky, E., Kiel, S., Peckmann, J. (2020): Mineral authigenesis within chemosynthetic microbial mats: Coated grain formation and phosphogenesis at a Cretaceous hydrocarbon seep, New Zealand. The Depositional Record 6:, DOI: 10.1002/dep2.123


Hagemann, M., Möke, F., Springer, A., Westermann, L., Frank, M., Wasmund, N., Bauwe, H. (2019): Cyanobacterium Nodularia spumigena strain CCY9414 accumulates polyphosphate under long-term P-limiting conditions. Aquatic Microbial Ecology 82: 265-274, DOI: 10.3354/ame01896

Haider, F., Sokolov, E.P., Timm, S., Hagemann, M., Blanco Rayón, E., Marigómez, I., Izagirre, U., Sokolova, I. (2019): Interactive effects of osmotic stress and burrowing activity on protein metabolism and muscle capacity in the soft shell clam Mya arenaria. Comparative Biochemistry and Physiology 228: 81–93, DOI: 10.1016/j.cbpa.2018.10.022

Jung., P., Schermer, M., Briegel-Williams, L., Baumann, K., Leinweber, P., Karsten, U., Lehnert, L., Achilles, S., Bendix, J., Büdel, B. (2019): Water availability shapes edaphic and lithic cyanobacterial communities in the Atacama Desert. Journal of Phycology 55: 1306-1318, DOI: 10.1111/jpy.12908

Löffler, N., Fiebig, J., Mulch, A., Tütken, T., Schmidt, B.C., Bajnai, D., Conrad, A.C., Wacker, U., Böttcher, M.E. (2019): Refining the temperature dependence of the oxygen and clumped isotopic compositions of structurally bound carbonate in apatite. Geochimica et Cosmochimica Acta 253: 19-38, DOI: 10.1016/j.gca.2019.03.002

Reyer, H., Oster, M., Wittenburg, D., Muráni, E., Ponsuksili, S., Wimmers, K. (2019): Genetic Contribution to Variation in Blood Calcium, Phosphorus, and Alkaline Phosphatase Activity in Pigs. Frontiers in Genetics 10:590:, DOI: 10.3389/fgene.2019.00590

Sokolov, E.P., Markert, S., Hinzke, T., Hirschfeld, C., Becher, D., Ponsuksili, S., Sokolova, I.M. (2019): Effects of hypoxia-reoxygenation stress on mitochondrial proteome and bioenergetics of the hypoxia-tolerant marine bivalve Crassostrea gigas. Journal of Proteomics 194: 99-111, DOI: 10.1016/j.jprot.2018.12.009

Sokolova, I., Sokolov, E.P., Haider, F., (2019): Mitochondrial Mechanisms Underlying Tolerance to Fluctuating Oxygen Conditions: Lessons from Hypoxia-Tolerant Organisms. Integrative and Comparative Biology 59: 938-952, DOI: 10.1093/icb/icz047

Sokolov⁠, E.P.⁠, Sokolova, I.M. (2019): Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45: 29-37, DOI: 10.1016/j.mito.2018.02.002

Wubuli, A., Reyer, H., Muráni, E., Ponsuksili, S., Wolf, P., Oster, M., Wimmers, K. (2019): Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs. International Journal of Molecular Sciences 20, 5576:, DOI: 10.3390/ijms20225576


Steinbauer, J., Kubis, C., Ludwig, R., Werner, T. (2018): Mechanistic Study on the Addition of CO2 to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach. ACS Sustainable Chemistry and Engineering 6: 10778–1078, DOI: 10.1021/acssuschemeng.8b02093.s001

Linda Adzigbli MNF Institut für Biowissenschaften, Meeresbiologie
Masuf Hasan FBN Genombiologie
Sandra Kammann MNF Institut für Biowissenschaften, Angewandte Ökologie und Phykologie
Prof. Dr. Ulf Karsten MNF Institut für Biowissenschaften, Angewandte Ökologie und Phykologie
PD Dr. Matthias Labrenz IOW Umweltmikrobiologie
Prof. Dr. Cornelia C. Metges FBN Institut für Ernährungsphysiologie 'Oskar Kellner'
Dr. Michael Oster FBN Genombiologie
Mariano Santoro IOW Umweltmikrobiologie
Dr. Evgeny Sokolov IOW Direktorat
Prof. Dr. Inna Sokolova MNF Institut für Biowissenschaften, Meeresbiologie
Prof. Dr. Klaus Wimmers FBN Genombiologie
PD Dr. Siriluck Wimmers FBN Genombiologie