Cluster IV: Molecular Biology of P - The central Role of P in Signaling and Metabolism from Cells to Ecosystems

The overarching goal is to unravel the central role of P as a metabolic, signaling and regulatory molecule from molecular to ecosystem levels. In fact, P acquisition, mobilisation and assimilation involve various molecular mechanisms in microorganisms, plants and animals. Moreover, P plays a key role in signalling at the level of ecosystems, organisms and cells. Projects in this Cluster aim to analyse the molecular mechanisms related to the uptake of P from the environment into the organism, the distribution, storage and mobilisation of P within the organisms and its essential roles in the cellular metabolism as well as in the crosstalk of microorganisms, cells and tissues.


Baclofen: Entwicklung effizienter Produktionsverfahren für die Darstellung von Baclofen und hiermit verwandter pharmazeutischer Produkte (BMWi, AIF, 01/2020-09/2023)

Graduiertenschule II: Leibniz-WissenschaftsCampus Phosphorforschung Rostock (WGL, 07/2019-11/2023)

MitoBOX: The mitochondrial basis of hypoxia tolerance in marine mollusks (DFG, 04/2019-09/2023)

P-FOWL: Epigenetics, molecular pathways, and data integration to derive biological networks related to myo-inositol and P utilization in two contrasting high-yielding laying hen strains (DFG, 2022-2025)

P-FOWL: Characterization of mineral utilisation by functional genomics in two contrasting high-yielding laying hen strains (DFG, 2022-2025)

VitD-Pig: Functional signals for vitamin D-mediated mineral utilization and related physiological determinants in pigs (DFG, 11/2022-10/2025)



Adzigbli, L., Ponsuksili, S., Sokolova, I. (2024): Mitochondrial responses to constant and cyclic hypoxia depend on the oxidized fuel in a hypoxia-tolerant marine bivalve Crassostrea gigas. Scientific Reports 14: 9658, DOI: 10.1038/s41598-024-60261-w

Hasan, M., Reyer, H., Oster, M, Trakooljul, N., Ponsuksilli, S., Magowan, E., Fischer, D.-C., Wimmers, K. (2024): Exposure to artificial ultraviolet-B light mediates alterations on the hepatic transcriptome and vitamin D metabolism in pigs. Journal of Steroid Biochemistry and Molecular Biology 236: 1-8, DOI: 10.1016/j.jsbmb.2023.106428

Kammann, S., Leinweber, P., Glaser, K., Schiefelbein, U., Dolnik, C., Mikhailyuk, T., Demchenko, E., Heilmann, E., Karsten, U. (2024): Successional development of the phototrophic community in biological soil crusts and soil development on Holocene deposits at the Baltic Sea coast. Frontiers in Ecology and Evolution 11: 1266209, DOI: 10.3389/fevo.2023.1266209

Kong, H., Sokolova, I.M. (2024): Oxidative phosphorylation rather than glycolysis is the primary energy source for sperm motility in the mussels Mytilus edulis. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 270: 110909, DOI: 10.1016/j.cbpb.2023.110909


Daş, G., Seyedalmoosavi, M.M., Schleifer, K., Mielenz, M., Metges, C.C. (2023): The validity of the bioaccumulation index versus the bioaccumulation factor for assessment of element accumulation in black soldier fly larvae. (In press), DOI:. Journal of Insects as Food and Feed 1-16, DOI: 10.3920/JIFF2023.0021

Glaser, K., Kammann, S., Plag, N., Dressler, M. (2023): Ecophysiological performance of terrestrial diatoms isolated from biocrusts of coastal sand dunes. Frontiers in Microbiology 14: 1279151, DOI: 10.3389/fmicb.2023.1279151

Hasan, M., Oster, M., Reyer, H., Wimmers, K., Fischer, D.C. (2023): Efficacy of dietary vitamin 3 and 25(OH)D3 on reproductive capacities, growth performance, immunity and bone development in pigs. British Journal of Nutrition 28: 1298-1307, DOI: 10.1017/S0007114523000442

Iqbal, M.A., Hadlich, F., Reyer, H., Oster, M., Trakooljul, N., Murani, E., Perdomo-Sabogal, A., Wimmers, K., Ponsuksili, S. (2023): RNA-Seq-based discovery of genetic variants and allele-specific expression of two layer lines and broiler chicken. Evolutionary Applications 16: 1135-1153, DOI: 10.1111/eva.13557

Kammann, S., Schiefelbein, U., Dolnik, C., Mikhailyuk, T., Demchenko, E., Karsten, U., Glaser, K. (2023): Successional Development of the Phototrophic Community in Biological Soil Crusts on Coastal and Inland Dunes. Biology 12: 1-26, DOI: 10.3390/biology12010058

Krieg, J., Stalljohann, G., Oster, M., Pfuhl, R., Reckels, B., Preissinger, W., Weber, M., Meyer, A., Feuerstein, D., Schneider, S. (2023): Stepwise Reduction of Dietary Phosphorus in Diets for Piglets and Fattening Pigs of Different Genetic Origin Housed under Various Station Environments—A Ringtest. Animals 13: 1-18, DOI: 10.3390/ani13111774

Li, S., Siengdee, P., Oster, M., Reyer, H., Wimmers, K. Ponsuksili, S. (2023): Transcriptome changes during osteogenesis of porcine mesenchymal stem cells derived from diferent types of synovial membranes and genetic background. Scientific Reports 13: 1-15, DOI: 10.1038/s41598-023-37260-4

Omotoso, A.O., Reyer, H., Oster, M., Ponsuksili, S., Wimmers, K. (2023): Jejunal microbiota of broilers fed varying levels of mineral phosphorus. Poultry Science 102: 1-11, DOI: 10.1016/j.psj.2023.103096

Omotoso, A.O., Reyer, H., Oster, M., Maak, S., Ponsuksili, S., Wimmers, K. (2023): Broiler physiological response to low phosphorus diets at different stages of production. Poultry Science 102: 1-13, DOI: 10.1016/j.psj.2022.102351

Ponsuksili , S., Hadlich, F., Perdomo-Sabogal, A., Reyer, H., Oster, M., Trakooljul, N., Iqbal, M.A., Schmucker, S., Stefanski, V., Roth, C., Camarinha Silva, A., Huber, K., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2023): The dynamics of molecular, immune and physiological features of the host and the gut microbiome and their interactions before and after onset of laying in two hen strains. Poultry Science 102: 102256, DOI: 10.1016/j.psj.2022.102256

Santoro, M., Hassenrück, C., Labrenz, M., Hagemann, M. (2023): Acclimation of Nodularia spumigena CCY9414 to inorganic phosphate limitation - Identification of the P-limitation stimulon via RNA-seq. Frontiers in Microbiology 13: 1082763, DOI: 10.3389/fmicb.2022.1082763


Adzigbli, L., Sokolov, E. P., Ponsuksili, S., Sokolova, I. M. (2022): Tissue- and substrate-dependent mitochondrial responses to acute hypoxia–reoxygenation stress in a marine bivalve (Crassostrea gigas). Journal of Experimental Biology 225: 1, DOI: 10.1242/jeb.243304

Adzigbli, L., Sokolov, E.P., Wimmers, K., Sokolova, I.M., Ponsuksili, S. (2022): Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells. Scientific Reports 12: 19881, DOI: 10.1038/s41598-022-24386-0

Falfushynska, H., Khatib, I., Kasianchuk, N., Lushchak, O., Horyn, O., Sokolova, I.M. (2022): Toxic effects and mechanisms of common pesticides (Roundup and chlorpyrifos) and their mixtures in a zebrafish model (Danio rerio). Science of the Total Environment 833: 155236, DOI: 10.1016/j.scitotenv.2022.155236

Fornara, D., Ball, E. M., Mulvenna, C., Reyer, H., Oster, M., Wimmers, K., Poulsen H.D., Rosemarin, A. (2022): Soil and Plant Responses to Phosphorus Inputs from Different Phytase-Associated Animal Diets. Agronomy 12: 1-16, DOI: 10.3390/agronomy12010130

Glaser, K., Van, A.T., Pushkareva, E., Barrantes, I., Karsten, U. (2022): Microbial Communities in Biocrusts Are Recruited From the Neighboring Sand at Coastal Dunes Along the Baltic Sea. Frontiers in Microbiology 13: 1-12, DOI: 10.3389/fmicb.2022.859447

Hasan, M., Oster, M., Reyer, H., Ponsuksili, S., Murani, E., Wolf, P., Fischer, D.-C., Wimmers, K. (2022): Tissue-Wide Expression of Genes Related to Vitamin D Metabolism and FGF23 Signaling following Variable Phosphorus Intake in Pigs. Metabolites 12: 1-15, DOI: 10.3390/metabo12080729

Iqbal, M.A., Reyer, H., Oster, M., Hadlich, F., Trakooljul, N., Perdomo-Sabogal, A., Schmucker, S., Stefanski, V., Roth, C., Camarinha Silva, A., Huber, K., Sommerfeld, V., Rodehutscord, M., Wimmers, K., Ponsuksili, S. (2022): Multi-Omics Reveals Different Strategies in the Immune and Metabolic Systems of High-Yielding Strains of Laying Hens. Frontiers in Genetics 13: 1-20, DOI: 10.3389/fgene.2022.858232

Mulvenna, C.C., McCormack, U.M., Magowan, E., McKillen, J., Bedford, M.R., Walk, C.L., Oster, M., Reyer, H., Wimmers, K., Fornara, D.A., Ball, M.E.E. (2022): The Growth Performance, Nutrient Digestibility, Gut Bacteria and Bone Strength of Broilers Offered Alternative, Sustainable Diets Varying in Nutrient Specification and Phytase Dose. Animals 12: 1-19, DOI: 10.3390/ani12131669

Pham, D. N., Sokolov, E. P., Falfushynska, H., Sokolova, I.M. (2022): Gone with sunscreens: Responses of blue mussels (Mytilus edulis) to a wide concentration range of a UV filter ensulizole. Chemosphere 309: 136736, DOI: 10.1016/j.chemosphere.2022.136736

Wu, F., Sokolov, E. P. , Khomich, A., Fettkenhauer, C., Schnell, G., Seitz, H., Sokolova, I.M. (2022): Interactive effects of ZnO nanoparticles and temperature on molecular and cellular stress responses of the blue mussel Mytilus edulis. Science of the Total Environment 818: 151785, DOI: 10.1016/j.scitotenv.2021.151785


Amorim, K., Piontkivska, H., Zettler, M. L., Sokolov, E., Hinzke, T., Nair, A. M., Sokolova, I. M. (2021): Transcriptional response of key metabolic and stress response genes of a nuculanid bivalve, Lembulus bicuspidatus from an oxygen minimum zone exposed to hypoxia-reoxygenation. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 256: 1-9, DOI: 10.1016/j.cbpb.2021.110617

Iqbal, M.A., Ali, A., Hadlich, F., Oster, M., Reyer, H., Trakooljul, N., Sommerfeld, V., Rodehutscord, M., Wimmers, K., Ponsuksili, S. (2021): Dietary phosphorus and calcium in feed affects miRNA profiles and their mRNA targets in jejunum of two strains of laying hens. Scientific Reports 11: 1-19, DOI: 10.1038/s41598-021-92932-3

Noor, M. N., Wu, F., Sokolov, E. P., Falfushynska, H., Timm, S., Haider, F., Sokolova, I. M. (2021): Salinity-dependent effects of ZnO nanoparticles on bioenergetics and intermediate metabolite homeostasis in a euryhaline marine bivalve, Mytilus edulis. Science of the Total Environment 774: 1-18, DOI: 10.1016/j.scitotenv.2021.145195

Omotoso, A.O., Reyer, H., Oster, M., Ponsuksili, S., Trakooljul, N., Muráni, E., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2021): Jejunal transcriptomic profiling of two layer strains throughout the entire production period. Scientific Reports 11: 1-11, DOI: 10.1038/s41598-021-99566-5

Oster, M., Reyer, H., Gerlinger, C., Trakooljul, N., Siengdee, P., Keiler, J., Ponsuksili, S., Wolf, P., Wimmers, K. (2021): mRNA Profiles of Porcine Parathyroid Glands Following Variable Phosphorus Supplies throughout Fetal and Postnatal Life. Biomedicines 9 [454]: 1-14, DOI: 10.3390/biomedicines9050454

Oster, M., Reyer, H., Keiler, J., Ball, E., Mulvenna, C., Ponsuksili, S., Wimmers, K. (2021): Comfrey (Symphytum spp.) as a feed supplement in pig nutrition contributes to regional resource cycles. Science of the Total Environment 796: 1-11, DOI: 10.1016/j.scitotenv.2021.148988

Ponsuksili, S., Hadlich, F., Reyer, H., Oster, M., Trakooljul, N., Iqbal, M.A., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2021): Genetic background and production periods shape the microRNA profiles of the gut in laying hens. Genomics 113 [4]: 1790-1801, DOI: 10.1016/j.ygeno.2021.04.018

Reyer, H., Oster, M., Ponsuksili, S., Trakooljul, N., Omotoso, A.O., Iqbal, M.A., Muráni, E., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2021): Transcriptional responses in jejunum of two layer chicken strains following variations in dietary calcium and phosphorus levels. BMC Genomics 22: 1-12, DOI: 10.1186/s12864-021-07814-9

Reyer, H., Sjöberg, P.J.R., Oster, M., Wubuli, A., Murani, E., Ponsuksili, S. Wolf, P. Wimmers, K. (2021): Mineral Phosphorus Supply in Piglets Impacts the Microbial Composition and Phytate Utilization in the Large Intestine. Microorganisms 9 [1197]: 1-10, DOI: 10.3390/microorganisms9061197

Roshan, S. K., Dumack, K., Bonkowski, M., Leinweber, P., Karsten, U., Glaser, K. (2021): Taxonomic and Functional Diversity of Heterotrophic Protists (Cercozoa and Endomyxa) from Biological Soil Crusts. Microorganisms 9: 1-14, DOI: 10.3390/microorganisms9020205

Sokolov, E. P., Adzigbli, L., Markert, S., Bundgaard, A., Fago, A., Becher, D., Hirschfeld, C., Sokolova, I. M. (2021): Intrinsic Mechanisms Underlying Hypoxia-Tolerant Mitochondrial Phenotype During Hypoxia-Reoxygenation Stress in a Marine Facultative Anaerobe, the Blue Mussel Mytilus edulis. Frontiers in Marine Science 8: 773734, DOI: 10.3389/fmars.2021.773734


Falfushynska, H.I., Sokolov, E., Piontkivska, H., Sokolova, I. (2020): The Role of Reversible Protein Phosphorylation in Regulation of the Mitochondrial Electron Transport System During Hypoxia and Reoxygenation Stress in Marine Bivalves. Frontiers in Marine Science 7: 467, DOI: 10.3389/fmars.2020.00467

Gussone, N., Böttcher, M.E., Conrad, A.C., Fiebig, J., Pelz, M., Grathoff, G., Schmidt, B.C. (2020): Calcium isotope fractionation upon experimental apatite formation. Chemical Geology 551: 119737, DOI: 10.1016/j.chemgeo.2020.119737

Oster, M., Reyer, H., Trakooljul, N., Weber, F. M., Xi, L., Muráni, E., Ponsuksili, S., Rodehutscord, M., Bennewitz, J., Wimmers, K. (2020): Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization. International Journal of Molecular Sciences 21, 2762:, DOI: 10.3390/ijms21082762

Ponsuksili, S., Reyer, H., Hadlich, F., Weber, F., Trakooljul, N., Oster, M., Siengdee, P., Muráni, E., Rodehutscord, M., Camarinha-Silva, A., Bennewitz, J., Wimmers, K. (2020): Identification of the Key Molecular Drivers of Phosphorus Utilization Based on Host miRNA-mRNA and Gut Microbiome Interactions. International Journal of Molecular Sciences 21, 2818:, DOI: 10.3390/ijms21082818

Siengdee, P., Oster, M., Reyer, H., Viergutz, T., Wimmers, K., Ponsuksili, S. (2020): Morphological and Molecular Features of Porcine Mesenchymal Stem Cells Derived From Different Types of Synovial Membrane, and Genetic Background of Cell Donors. Frontiers in Cell and Developmental Biology 8: 601212, DOI: 10.3389/fcell.2020.601212

Sommerfeld, V., Huber, K., Bennewitz, J., Camarinha-Silva, A., Hasselmann, M., Ponsuksili, S., Seifert, J., Stefanski, V., Wimmers, K., Rodehutscord, M. (2020): Phytate degradation, myo-inositol release, and utilization of phosphorus and calcium by two strains of laying hens in five production periods. Poultry Science 99: 6797-6808, DOI: 10.1016/j.psj.2020.08.064

Sommerfeld, V., Omotoso, A.O., Oster, M., Reyer, H., Camarinha-Silva, A., Hasselmann, M., Huber, K., Ponsuksili, S., Seifert, J., Stefanski, V., Wimmers, K., Rodehutscord, M. (2020): Phytate degradation, transcellular mineral transporters, and mineral utilization by two strains of laying hens as affected by dietary phosphorus and calcium. Animals 10: 1-21, DOI: 10.3390/ani10101736

Zwicker, J., Smrzka, D., Steindl, F., Böttcher, M.E., Libowitzky, E., Kiel, S., Peckmann, J. (2020): Mineral authigenesis within chemosynthetic microbial mats: Coated grain formation and phosphogenesis at a Cretaceous hydrocarbon seep, New Zealand. The Depositional Record 6:, DOI: 10.1002/dep2.123


Hagemann, M., Möke, F., Springer, A., Westermann, L., Frank, M., Wasmund, N., Bauwe, H. (2019): Cyanobacterium Nodularia spumigena strain CCY9414 accumulates polyphosphate under long-term P-limiting conditions. Aquatic Microbial Ecology 82: 265-274, DOI: 10.3354/ame01896

Haider, F., Sokolov, E.P., Timm, S., Hagemann, M., Blanco Rayón, E., Marigómez, I., Izagirre, U., Sokolova, I. (2019): Interactive effects of osmotic stress and burrowing activity on protein metabolism and muscle capacity in the soft shell clam Mya arenaria. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 228: 81–93, DOI: 10.1016/j.cbpa.2018.10.022

Jung., P., Schermer, M., Briegel-Williams, L., Baumann, K., Leinweber, P., Karsten, U., Lehnert, L., Achilles, S., Bendix, J., Büdel, B. (2019): Water availability shapes edaphic and lithic cyanobacterial communities in the Atacama Desert. Journal of Phycology 55: 1306-1318, DOI: 10.1111/jpy.12908

Löffler, N., Fiebig, J., Mulch, A., Tütken, T., Schmidt, B.C., Bajnai, D., Conrad, A.C., Wacker, U., Böttcher, M.E. (2019): Refining the temperature dependence of the oxygen and clumped isotopic compositions of structurally bound carbonate in apatite. Geochimica et Cosmochimica Acta 253: 19-38, DOI: 10.1016/j.gca.2019.03.002

Reyer, H., Oster, M., Wittenburg, D., Muráni, E., Ponsuksili, S., Wimmers, K. (2019): Genetic Contribution to Variation in Blood Calcium, Phosphorus, and Alkaline Phosphatase Activity in Pigs. Frontiers in Genetics 10:590:, DOI: 10.3389/fgene.2019.00590

Sokolov, E.P., Markert, S., Hinzke, T., Hirschfeld, C., Becher, D., Ponsuksili, S., Sokolova, I.M. (2019): Effects of hypoxia-reoxygenation stress on mitochondrial proteome and bioenergetics of the hypoxia-tolerant marine bivalve Crassostrea gigas. Journal of Proteomics 194: 99-111, DOI: 10.1016/j.jprot.2018.12.009

Sokolova, I., Sokolov, E.P., Haider, F., (2019): Mitochondrial Mechanisms Underlying Tolerance to Fluctuating Oxygen Conditions: Lessons from Hypoxia-Tolerant Organisms. Integrative and Comparative Biology 59: 938-952, DOI: 10.1093/icb/icz047

Sokolov⁠, E.P.⁠, Sokolova, I.M. (2019): Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45: 29-37, DOI: 10.1016/j.mito.2018.02.002

Wubuli, A., Reyer, H., Muráni, E., Ponsuksili, S., Wolf, P., Oster, M., Wimmers, K. (2019): Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs. International Journal of Molecular Sciences 20, 5576:, DOI: 10.3390/ijms20225576


Steinbauer, J., Kubis, C., Ludwig, R., Werner, T. (2018): Mechanistic Study on the Addition of CO2 to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach. ACS Sustainable Chemistry and Engineering 6: 10778–1078, DOI: 10.1021/acssuschemeng.8b02093.s001

Linda Adzigbli FBN Genombiologie
Masuf Hasan FBN Genombiologie
Sandra Kammann MNF Institut für Biowissenschaften, Angewandte Ökologie und Phykologie
Prof. Dr. Ulf Karsten MNF Institut für Biowissenschaften, Angewandte Ökologie und Phykologie
PD Dr. Matthias Labrenz IOW Umweltmikrobiologie
Prof. Dr. Cornelia C. Metges FBN Institut für Ernährungsphysiologie 'Oskar Kellner'
Dr. Michael Oster FBN Genombiologie
Mariano Santoro IOW Umweltmikrobiologie
Prof. Dr. Inna Sokolova MNF Institut für Biowissenschaften, Meeresbiologie
Prof. Dr. Klaus Wimmers FBN Genombiologie
PD Dr. Siriluck Wimmers FBN Genombiologie